Studies on Chemotherapeutics XXV

Studies on echinococcosis. XXV. Anthelmintic action of drugs on larval Echinococcus multilocularis in vitro.

Studies on monoamine oxidase. (Report XXV). Effects of alcohols on beef liver mitochondrial monoamine oxidase.

The effects of alcohols on MAO activity in beef and rat liver mitochondria were studied. MAO activity was determined manometrically using tyramine (1× 10-2 M) as substrate and expressed as O2 uptake in 60 min. At concentrations of 0.1 to 10%, methanol and ethanol increased MAO activity in both beef and rat liver mitochondria. Activation of MAO by ethanol was reversib...

Oxidative phosphorylation in fractionated bacterial systems. XXV. Studies on the involvement of metal in Mycobacterium phlei.

The involvement of metal in oxidation and coupled phosphorylation by cell-free preparations of Mycobacterium phlei was examined. The oxidation of succinate was inhibited by metal-chelating agents, but with /3-hydroxybutyrate, chelating agents exhibited an uncoupling effect. The site of inhibition was found to be between the flavoprotein and the cytochrome b regions of the electron transport cha...

The structures of tridecaptins B and C (studies on antibiotics from the genus Bacillus. XXV).

On examining the structures of the antibiotics tridecaptins B and C, the constituent amino acids were separated and their chiralities were determined. The constituent fatty acids were identified by gas chromatography and mass spectrometry. Cleavage with N-bromosuccinimide and sequential analysis by EDMAN degradation demonstrates the sequence of the C-terminal side of tridecaptins B and C. Deacy...

Transactions on Computational Collective Intelligence XXV